SDR vs HDR
At the bottom of the color panel, you can toggle between SDR and HDR modes available to the system.
For the most part, you will want sRGB for SDR on both MacOS and Windows, HDR10 for HDR on Windows, and Linear P3 EDR for HDR on MacOS.
The OCIO presets panel reacts to which mode you are in and provides appropriate templates for viewing media.

Color output with OCIO
SDR mode
In SDR mode, use an sRGB or a bt.1886 output for a standard display-referred result.
HDR mode (Windows)
With Windows HDR10 mode enabled, you should use Rec.2100 PQ or PQ BT.2021 or something similarly names for the output.
HDR mode (macOS — EDR)
In Linear P3 EDR mode you will want to use one the matching output module in ACES 2.0 or Blender 5.1 configs.