Settings
Open Settings with Ctrl + , (or Tools → Settings…). The panel reveals in the Left Rail under the Settings section.

Image Sequence Settings
Image sequence threading and cache window sizes are already set fairly aggressively by default. Consider making them smaller on a computer with fewer threads or less RAM; increasing these is unlikely to be beneficial.
A/V Sync Offset
A default A/V sync offset trim is applied at session start. Here you can customize them to your system. The single-source flow and dual-view flow store separate offsets — your sync trim for compositing two sources doesn’t get applied to single-source playback and vice versa.
Hover Thumbnails
Toggle the timeline hover thumbnail preview on or off (low-RAM systems or focus-mode users may prefer it off).